David C Montefiori Selected Research

AIDS Vaccines

1/2018	IDLV-HIV-1 Env vaccination in non-human primates induces affinity maturation of antigen-specific memory B cells.
1/2018	Control of Heterologous Simian Immunodeficiency Virus SIVsmE660 Infection by DNA and Protein Coimmunization Regimens Combined with Different Toll-Like-Receptor-4-Based Adjuvants in Macaques.
1/2018	HIV vaccine candidate activation of hypoxia and the inflammasome in CD14+ monocytes is associated with a decreased risk of SIVmac251 acquisition.
1/2017	HIV/AIDS Vaccine Candidates Based on Replication-Competent Recombinant Poxvirus NYVAC-C-KC Expressing Trimeric gp140 and Gag-Derived Virus-Like Particles or Lacking the Viral Molecule B19 That Inhibits Type I Interferon Activate Relevant HIV-1-Specific B and T Cell Immune Functions in Nonhuman Primates.
1/2017	Immunogenicity of a novel Clade B HIV-1 vaccine combination: Results of phase 1 randomized placebo controlled trial of an HIV-1 GM-CSF-expressing DNA prime with a modified vaccinia Ankara vaccine boost in healthy HIV-1 uninfected adults.
1/2017	Antibody-virus co-evolution in HIV infection: paths for HIV vaccine development.
1/2017	Basis and Statistical Design of the Passive HIV-1 Antibody Mediated Prevention (AMP) Test-of-Concept Efficacy Trials.
10/2016	Virus-Like Particles Displaying Trimeric Simian Immunodeficiency Virus (SIV) Envelope gp160 Enhance the Breadth of DNA/Modified Vaccinia Virus Ankara SIV Vaccine-Induced Antibody Responses in Rhesus Macaques.
3/2015	Balance of cellular and humoral immunity determines the level of protection by HIV vaccines in rhesus macaque models of HIV infection.
11/2014	HIV-specific humoral responses benefit from stronger prime in phase Ib clinical trial.

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David C Montefiori Research Topics

Disease

178	Infections 10/2022 - 01/2002
36	Viremia 01/2022 - 03/2002
30	Acquired Immunodeficiency Syndrome (AIDS) 10/2019 - 01/2002
22	Vaccinia 01/2019 - 01/2002
21	HIV Infections (HIV Infection) 01/2022 - 08/2003
15	Virus Diseases (Viral Diseases) 10/2021 - 01/2002
13	COVID-19 01/2022 - 01/2021
9	Disease Progression 01/2020 - 01/2002
8	Communicable Diseases (Infectious Diseases) 04/2021 - 01/2003
8	Persistent Infection 08/2015 - 01/2002
7	Vesicular Stomatitis 01/2019 - 09/2004
5	Breakthrough Infections 01/2022 - 01/2014
3	Pneumonia (Pneumonitis) 02/2021 - 01/2021
2	Edema (Dropsy) 02/2021 - 01/2021
2	Reinfection 01/2021 - 01/2021
2	Neoplasms (Cancer) 01/2021 - 01/2019
2	Hypersensitivity (Allergy) 11/2019 - 10/2007
2	Human Influenza (Influenza) 11/2018 - 01/2014
1	COVID-19 related pediatric multisystem inflammatory disease 01/2022
1	Myocarditis (Carditis) 01/2022
1	Pericarditis 01/2022
1	Lymphopenia (Lymphocytopenia) 10/2021
1	Malaria 07/2020
1	Back Pain (Backache) 01/2018
1	Abdominal Pain (Pain, Abdominal) 01/2018
1	Hypoxia (Hypoxemia) 01/2018
1	Dizziness (Lightheadedness) 01/2018

Drug/Important Bio-Agent (IBA)

122	VaccinesIBA 10/2022 - 01/2002
55	AntibodiesIBA 01/2022 - 03/2002
48	Neutralizing AntibodiesIBA 10/2022 - 03/2002
36	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 01/2002
31	Broadly Neutralizing AntibodiesIBA 01/2022 - 02/2012
31	Proteins (Proteins, Gene)FDA Link 01/2021 - 03/2002
25	AIDS VaccinesIBA 01/2018 - 01/2002
21	Immunoglobulin G (IgG)IBA 12/2021 - 12/2008
21	EpitopesIBA 01/2021 - 01/2002
13	Glycoproteins (Glycoprotein)IBA 12/2021 - 05/2008
13	AntigensIBA 01/2021 - 03/2004
13	Monoclonal AntibodiesIBA 01/2020 - 02/2003
13	Immunoglobulin A (IgA)IBA 01/2019 - 02/2012
12	Antiviral Agents (Antivirals)IBA 01/2022 - 01/2002
8	GP 140IBA 01/2020 - 05/2008
8	A-Form DNA (A-DNA)IBA 11/2019 - 07/2002
7	2019-nCoV Vaccine mRNA-1273IBA 01/2022 - 08/2021
7	Peptides (Polypeptides)IBA 07/2020 - 05/2008
6	RNA (Ribonucleic Acid)IBA 01/2022 - 04/2003
6	env Gene ProductsIBA 11/2019 - 08/2011
6	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 01/2017 - 09/2006
6	DNA VaccinesIBA 06/2007 - 01/2003
5	CytokinesIBA 02/2021 - 11/2002
5	SAIDS VaccinesIBA 04/2015 - 07/2005
4	Immunoglobulins (Immunoglobulin)IBA 12/2021 - 09/2021
3	BNT162 VaccineIBA 10/2022 - 10/2021
3	Ad26COVS1IBA 01/2022 - 10/2021
3	NucleosidesIBA 04/2021 - 01/2018
3	Messenger RNA (mRNA)IBA 04/2021 - 01/2018
3	Fc Receptors (Fc Receptor)IBA 02/2021 - 11/2016
3	aluminum sulfate (alum)IBA 01/2021 - 10/2003
3	Protein Subunits (Protein Subunit)IBA 01/2021 - 04/2004
3	EnzymesIBA 01/2020 - 07/2005
3	MF59 oil emulsionIBA 01/2018 - 02/2015
3	AIDSVAXIBA 01/2018 - 08/2010
3	MVA vaccineIBA 12/2017 - 05/2002
3	Indicators and Reagents (Reagents)IBA 10/2017 - 08/2005
3	Recombinant DNA (Recombinant DNA Research)IBA 02/2012 - 03/2011
3	Viral RNAIBA 07/2006 - 01/2002
2	DH1047IBA 01/2022 - 04/2021
2	COVID-19 VaccinesIBA 01/2022 - 10/2021
2	Lipid NanoparticlesIBA 04/2021 - 12/2020
2	Blocking AntibodiesIBA 02/2021 - 01/2021
2	Tenofovir (Viread)FDA Link 01/2021 - 07/2006
2	ImmunosorbentsIBA 01/2020 - 07/2008
2	CD40 Ligand (CD40L)IBA 01/2020 - 09/2014
2	Polysaccharides (Glycans)IBA 12/2019 - 02/2012
2	Complement System Proteins (Complement)IBA 01/2017 - 01/2014
2	Immunoglobulin M (IgM)IBA 12/2016 - 12/2008
2	Immunologic Factors (Immunomodulators)IBA 05/2016 - 07/2012
2	Interleukin-2 (IL2)IBA 04/2013 - 03/2005
2	Interleukin-15 (Interleukin 15)IBA 04/2013 - 06/2007
2	Anti-Infective Agents (Microbicides)IBA 06/2010 - 04/2009
2	Biological ProductsIBA 03/2010 - 03/2009
2	PhosphatidylserinesIBA 07/2008 - 01/2008
2	Cardiolipins (Cardiolipin)IBA 07/2008 - 01/2008
2	Interleukin-12 (IL 12)IBA 06/2007 - 07/2005
1	Ferritins (Ferritin)IBA 02/2022
1	sortase AIBA 02/2022
1	Vorinostat FDA Link 01/2022
1	Dihydrotachysterol (AT 10)IBA 01/2022
1	COVA1-18IBA 10/2021
1	Liposomes (Liposome)IBA 07/2020
1	Viral VaccinesIBA 01/2019
1	Bispecific AntibodiesIBA 01/2018
1	InflammasomesIBA 01/2018
1	AluminumIBA 01/2018
1	Aspartate Aminotransferases (Aspartate Transaminase)IBA 01/2018
1	Tyrosine (L-Tyrosine)FDA Link 01/2018
1	Biomarkers (Surrogate Marker)IBA 01/2017

Therapy/Procedure

6	Therapeutics 01/2022 - 04/2003
2	Art Therapy 10/2020 - 01/2017
1	Intramuscular Injections 01/2018